2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2772
    8-Epideoxyloganic acid 88668-99-9 99.95%
    8-Epideoxyloganic acid (7-Deoxy-8-epiloganic acid), an iridoid glucoside, can be found in Incarvillea delavayi. 8-Epideoxyloganic acid exhibits weak antinociceptive activity.
    8-Epideoxyloganic acid
  • HY-N3182
    N-Methylnuciferine 754919-24-9 98.29%
    N-Methylnuciferine, an alkaloid from Lotus Plumule, ameliorate lipopolysaccharide-induced depression-like behavior.
    N-Methylnuciferine
  • HY-N3187
    Nimbin 5945-86-8 ≥98.0%
    Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections.
    Nimbin
  • HY-N3204
    Neoechinulin A 51551-29-2 ≥98.0%
    Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice.
    Neoechinulin A
  • HY-N3473
    Isomaculosidine 518-96-7 99.42%
    Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells.
    Isomaculosidine
  • HY-N3710
    Dehydrocrenatidine 65236-62-6 ≥98.0%
    Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain.
    Dehydrocrenatidine
  • HY-N3841
    ε-​Viniferin 62218-08-0 ≥98.0%
    ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity.
    ε-​Viniferin
  • HY-N3979
    Grossamide 80510-06-1 ≥98.0%
    Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects.
    Grossamide
  • HY-N4191
    Isorosmanol 93780-80-4 99.40%
    Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis.
    Isorosmanol
  • HY-N4206
    Leptomerine 22048-97-1 99.90%
    Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC50 of 2.5 μM. Anticholinesterasic activity.
    Leptomerine
  • HY-N4325
    Onjisaponin Z 1078708-72-1
    Onjisaponin Z is a natural product isolated from Radix Polygalae.
    Onjisaponin Z
  • HY-N5075
    Quercetin 3-O-glucoside-7-O-rhamnoside 18016-58-5
    Quercetin 3-O-glucoside-7-O-rhamnoside is a member of flavonoid glycosides group with an inhibitory activity on the CNS.
    Quercetin 3-O-glucoside-7-O-rhamnoside
  • HY-N5101
    Kobusin 36150-23-9 99.93%
    Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel.
    Kobusin
  • HY-N6574
    Marinobufogenin 470-42-8 ≥99.0%
    Marinobufogenin is a strong inhibitor of Na+/K+ ATPase that has been identified in mammalian plasma.
    Marinobufogenin
  • HY-N6640
    2-O-Acetyl-20-hydroxyecdysone 19536-25-5 99.61%
    2-O-Acetyl-20-hydroxyecdysone, an ecdysterones in insects and terrestrial plants, inhibits amyloid-β42 (Aβ42)-induced cytotoxicity. 2-O-Acetyl-20-hydroxyecdysone could decrease Aβ oligomer formation through promotion of fibrogenesis, transforming Aβ oligomers to the low-toxicity fibrils.
    2-O-Acetyl-20-hydroxyecdysone
  • HY-N6738
    Bafilomycin B1 88899-56-3 98.22%
    Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets.
    Bafilomycin B1
  • HY-N6803
    Polygalaxanthone XI 857859-82-6 ≥99.0%
    Polygalaxanthone XI, a xanthone glycoside isolated from the cortexes of Polygala tenuifolia, can be used in the study of expectorant, and tranquilizing agent.
    Polygalaxanthone XI
  • HY-N6906
    Oleuroside 116383-31-4
    Oleuroside is a phenolic secoiridoid in olive. Oleuroside can protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing.
    Oleuroside
  • HY-N6960
    L-Stepholidine 16562-13-3 99.79%
    L-Stepholidine (Stepholidine) exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction.
    L-Stepholidine
  • HY-N7034
    Magnolioside 20186-29-2 98.99%
    Magnolioside, isolated from Angelica gigas Nakai (Umbelliferae), exhibits significant neuroprotective activities against glutamate-induced toxicity.
    Magnolioside
Cat. No. Product Name / Synonyms Application Reactivity